Enabling Exosomes Enrichment Through Microfluidic Mechanoporation
Our engineering platform uses continuous microfluidic mechanoporation to load exosomes with therapeutic RNA and other payloads. By creating temporary, controlled pores as vesicles pass through micro-channels, we achieve efficient, scalable, and precise cargo loading while preserving their natural regenerative properties.
Mechanoporation: Unlocking New Therapeutic Possibilities
This microfluidic technique enables consistent and high-efficiency loading of exosomes with a wide range of therapeutic substances. The result is a versatile, robust, and automation-ready approach to producing enriched exosomes for regenerative medicine.
Different drug substances can be loaded using the platform. The process has been validated with miRNA, proteins, and water-soluble therapeutic compounds.
All exosomes in the solution eventually pass through the chip’s nano-channels, with a maximum of one or two per channel at a time.
The absorption efficiency is around 10-fold higher compared to passive loading, while preserving exosomes integrity
The microfluidic format is inherently highly compatible with a continuous process format and automation, which will positively impact product quality.
Our mechanoporation platform includes dedicated solutions for both small-scale development and large-scale manufacturing, supporting seamless progression from early R&D to clinical studies.
A Scalable System for Clinical-Grade Production
Designed for rapid testing and optimization, this single microfluidic chip produces GLP-grade material suitable for preclinical characterization and for evaluating new therapeutic candidates.
An integrated, automated system built forlarge-scale production of GMP-grade exosomes, delivering the volumes requiredfor clinical development and beyond
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